ÕÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍ͸ ³ ³ ³ ------Cortisone Drugs (Steroids)------ ³ ³ ³ ³ A. Methylprednisolone ³ ³ B. Prednisone ³ ³ ³ ÔÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍ; METHYLPREDNISOLONE BRAND NAMES A-methaPred Medralone-80 dep Medalone Medrol Depoject Medrol Enpak Depo-Medrol Medrone Depo-medrone Medrone-80 Depopred Mepred-40 Depo-Pred-40 Methylone Depo-Pred-80 m-Prednisol Depo-Predate Pre-Dep Duralone Pro-Dep-40 Duralone-40 Pro-Dep-80 Duralone-80 Rep-Pred Durameth Solu-Medrol Medralone Solu-medrone Medralone-40 BASIC INFORMATION Habit forming? No Prescription needed? Yes Available as generic? Yes Drug class: Cortisone drug (adrenal corticosteroid) USES Reduces inflammation caused by many different medical problems. Treatment for some allergic diseases, blood disorders, kidney diseases, asthma and emphysema. Replaces corticosteroid deficiencies. DOSAGE AND USAGE INFORMATION How to take: Tablet--Swallow with liquid or food to lessen stomach irritation. If you can't swallow whole, crumble tablet and take with liquid or food. Injection--Take under doctor's supervision. When to take: At the same times each day. Take once-a-day or once-every-other-day doses in mornings. If you forget a dose: Several-doses-per-day prescription--Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose). Once-a-day dose or less--Wait for next dose. Double this dose. What drug does: Decreases inflammatory responses. Time lapse before drug works: 2 to 4 days. Don't take with: See interaction column and consult doctor. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What to Do _______________________________________________________________________ Life-threatening: Hives, rash, intense Seek emergency treatment itching, faintness immediately. soon after a dose (anaphylaxis). Common: Acne, poor wound Continue. Call doctor when healing, thirst, convenient. indigestion, nausea, vomiting, decreased growth in children. Infrequent: Black, bloody or Discontinue. Seek emergency tarry stools. treatment. Blurred vision, Discontinue. Call doctor halos around lights, right away. sore throat, fever, muscle cramps, swollen legs or feet. Mood change, Continue. Call doctor when insomnia, convenient. restlessness, frequent urination, weight gain, round face, fatigue, weakness, TB recurrence, irregular menstrual periods. Rare: Irregular heartbeat. Discontinue. Seek emergency treatment. Rash, numbness or Discontinue. Call doctor tingling in hands right away. or feet, pancreatitis, thrombophlebitis, hallucinations, convulsions. OVERDOSE Symptoms: Headache, convulsions, heart failure. What to do: Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately. See emergency information. WARNINGS AND PRECAUTIONS Don't take if: You are allergic to any cortisone drug. You have tuberculosis or fungus infection. You have herpes infection of eyes, lips or genitals. Before you start, consult your doctor: If you have had tuberculosis. If you have congestive heart failure. If you have diabetes, peptic ulcer, glaucoma, underactive thyroid, high blood pressure, myasthenia gravis, blood clots in legs or lungs. Over age 60: Adverse reactions and side effects may be more frequent and severe than in younger persons. Likely to aggravate edema, diabetes or ulcers. Likely to cause cataracts and osteoporosis (softening of the bones). Pregnancy: Risk to unborn child outweighs drug benefits. Don't use. Breast-feeding: Drug passes into milk. avoid drug or discontinue nursing until you finish mecicine. Consult doctor for advice on maintaining milk supply. Infants and children: Use only under medical supervision. Prolonged use: Retards growth in children. Possible glaucoma, cataracts, diabetes, fragile bones and thin skin. Functional dependence. Skin & sunlight: No problems expected. Driving, piloting or hazardous work: No problems expected. Discontinuing: Don't discontinue without doctor's advice until you complete prescribed dose, even though symptoms diminish or disappear. Drug affects your response to surgery, illness, injury or stress for 2 years after discontinuing. Tell anyone who takes medical care of you within 2 years about drug. Others: Avoid immunizations if possible. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Drug Class Combined Effect ______________________________________________________________________ Amphotericin B Potassium depletion. Anticholinergics Possible glaucoma. Anticoagulants (oral) Decreased anticoagulant effect Anticonvulsants (hydantoin) Decreased methylprednisolone effect. Antidiabetics (oral) Decreased antidiabetic effect. Antihistamines Decreased methylprednisolone effect. Aspirin Increased methylprednisolone effect. Attenuated virus vaccines Possible viral infection. Barbiturates Decreased methylprednisolone effect. Oversedation. Chloral hydrate Decreased methylprednisolone effect. Chlorthalidone Potassium depletion. Cholestyramine Decreased methylprednisolone absorption. Cholinergics Decreased cholinergic effect. Colestipol Decreased methylprednisolone effect. Contraceptives (oral) Increased methylprednisolone effect. Digitalis preparations Dangerous potassium depletion. Possible digitalis toxicity. Diuretics (thiazide,) Potassium depletion. Ephedrine Decreased methylprednisolone effect. Estrogens Increased methylprednisolone effect. Ethacrynic acid Potassium depletion. Furosemide Potassium depletion. Glutethimide Decreased methylprednisolone effect. Indapramide Possible excessive potassium loss, causing dangerous heartbeat irregularity. Indomethacin Increased methylprednisolone effect. Insulin Decreased insulin effect. Isoniazid Decreased isoniazid effect. Mitotane Decreased methylprednisolone effect. Non-steroidal Increased risk of ulcers and anti-inflammatory drugs methylprednisolone effect. Oxyphenbutazone Possible ulcers. Phenobarbital Decreased methylprednisolone effect. Phenylbutazone Possible ulcers. Salicylates Decreased salicylate effect. Theophylline Possible increased theophylline effect. Potassium supplements Decreased potassium effect. Rifampin Decreased emthylprednisolone effect. Sympathomimetics Possible glaucoma. POSSIBLE INTERACTION WITH OTHER SUBSTANCES Interacts With Combined Effect ________________________________________________________________________ Alcohol Risk of stomach ulcers. Beverages No proven problems. Cocaine Overstimulation. Avoid. Foods No proven problems. Marijuana Decreased immunity. Tobacco Increased methylprednisolone effect. Possible toxicity. PREDNISONE BRAND NAMES Apo-Prednisone Panasol Colisone Paracort Cortan Prednicen-M Deltasone SK-Prednisone Liquid-Pred Sterapred Meticorten Sterazolidin Novoprednisone Winpred Orasone BASIC INFORMATION Habit forming? No Prescription needed? Yes Available as generic? Yes Drug class: Cortisone drug (adrenal corticosteroid) USES Reduces inflammation caused by many different medical problems. Treatment for some allergic diseases, blood disorders, kidney diseases, asthma and emphysema. Replaces corticosteroid deficiencies. DOSAGE AND USAGE INFORMATION How to take: Tablet or liquid--Swallow with liquid or food to lessen stomach irritation. If you can't swallow whole, crumble tablet. When to take: At the same times each day. Take once-a-day or once-every-other-day doses in mornings. If you forget a dose: Several-doses-per-day prescription--Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose). Once-a-day dose or less--Wait for next dose. Double this dose. What drug does: Decreases inflammatory responses. Time lapse before drug works: 2 to 4 days. Don't take with: See interaction column and consult doctor. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What To Do __________________________________________________________________ Life-threatening: Hives, rash, intense Seek emergency treatment itching, faintness immediately. soon after a dose (anaphylaxis). Common: Acne, poor wound Continue. Call doctor healing, thirst, when convenient. indigestion, nausea, vomiting, decreased growth in children. Infrequent: Black, bloody or Discontinue. Seek emergency tarry stool. treatment. Blurred vision, Discontinue. Call doctor halos around lights, right away. sore throat, fever, muscle cramps. Mood change, fatigue, Continue. Call doctor insomnia, weakness, when convenient. restlessness, frequent urination, weight gain, round face, TB recurrence, irregular menstrual periods. Rare: Irregular heartbeat. Discontinue. Seek emergency treatment. Skin rash, fever Discontinue. Call doctor joint pain, acute right away. psychosis, hair loss, pancreatitis, numbness or tingling in hands or feet, convulsions, thrombophlebitis, hallucinations. OVERDOSE Symptoms: Headache, convulsions, heart failure. What to do: Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately. See emergency information. WARNINGS AND PRECAUTIONS Don't take if: You are allergic to any cortisone drug. You have tuberculosis or fungus infection. You have herpes infection of eyes, lips or genitals. Before you start, consult your doctor: If you have had tuberculosis. If you have congestive heart failure. If you have diabetes. If you have peptic ulcer. If you have glaucoma. If you have underactive thyroid. If you have high blood pressure. If you have myasthenia gravis. If you have blood clots in legs or lungs. Over age 60: Adverse reactions and side effects may be more frequent and severe than in younger persons. Likely to aggravate edema, diabetes or ulcers. Likely to cause cataracts and osteoporosis (softening of the bones). Pregnancy: Risk to unborn child outweighs drug benefits. Don't use. Breast-feeding: Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply. Infants and children: Use only under medical supervision. Prolonged use: Retards growth in children. Possible glaucoma, cataracts, diabetes, fragile bones and thin skin. Functional dependence. Skin and Sunlight: No problems expected. Driving, piloting or hazardous work: No problems expected. Discontinuing: Don't discontinue without doctor's advice until you complete prescribed dose, even though symptoms diminish or disappear. Drug affects your response to surgery, illness, injury or stress for 2 years after discontinuing. Tell anyone who takes medical care of you within 2 years about drug. Others: Avoid immunizations if possible. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Drug Class Combined effect ________________________________________________________________ Amphotericin B Potassium depletion. Anticholinergics Possible glaucoma. Anticoagulants (oral) Decreased anticoagulant effect Anticonvulsants (hydantoin) Decreased prednisone effect. Antidiabetics (oral) Decreased antidiabetic effect. Antihistamines Decreased prednisone effect. Aspirin Increased prednisone effect. Attenuated virus vaccines Possible viral infection. Barbiturates Decreased prednisone effect. Oversedation. Chloral hydrate Decreased prednisone effect. Chlorthalidone Potassium depletion. Cholestyramine Decreased prednisone absorption. Cholinergics Decreased cholinergic effect. Colestipol Decreased prednisone absorption. Contraceptives (oral) Increased prednisone effect. Digitalis preparations Dangerous potassium depletion. Possible digitalis toxicity. Diuretics, thiazide Potassium depletion. Ethacrynic acid Potassium depletion. Ephedrine Decreased prednisone effect. Estrogens Increased prednisone effect. Furosemide Potassium depletion. Glutethimide Decreased prednisone effect. Indapamide Possible excessive potassium loss, causing dangerous heartbeat irregularity. Indomethacin Increased prednisone effect. Insulin Decreased insulin effect. Isoniazid Decreased isoniazid effect. Mitotane Decreased prednisone effect. Non-steroidal Increased risk of ulcers and anti-inflammatory drugs prednisone effect. Phenobarbital Decreased prednisone effect. Oxyphenbutazone Possible ulcers. Phenylbutazone Possible ulcers. Potassium supplements Decreased potassium effect. Rifampin Decreased prednisone effect. Salicylates Decreased salicylate effect. Sympathomimetics Possible glaucoma. Theophylline Possible increased theophylline effect. POSSIBLE INTERACTION WITH OTHER SUBSTANCES Interacts with Combined effect ________________________________________________________________ Alcohol: Risk of stomach ulcers. Beverages: No proven problems. Cocaine: Overstimulation. Avoid. Foods: No proven problems. Marijuana: Decreased immunity. Tobacco: Increased prednisone effect. Possible toxicity. Downloaded From P-80 International Information Systems 304-744-2253